반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[OH:10].F[C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:13]=1[N+:19]([O-:21])=[O:20].[F:22][C:23]1[CH:24]=[CH:25][C:26]([O:30][C:31]2[C:36]([O:37][CH3:38])=[CH:35][CH:34]=[CH:33][C:32]=2[F:39])=[C:27]([CH:29]=1)[NH2:28].[NH2:40][C:41]1[S:42][CH:43]=[CH:44][N:45]=1>>[F:18][C:15]1[CH:16]=[CH:17][C:12]([O:10][C:3]2[C:4]([O:8][CH3:9])=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])=[C:13]([N+:19]([O-:21])=[O:20])[CH:14]=1.[F:22][C:23]1[CH:24]=[CH:25][C:26]([O:30][C:31]2[C:36]([O:37][CH3:38])=[CH:35][CH:34]=[CH:33][C:32]=2[F:39])=[C:27]([NH:28][C:3]([NH:40][C:41]2[S:42][CH:43]=[CH:44][N:45]=2)=[O:10])[CH:29]=1참가 물질
6
반응물 4
생성물 2
실험 절차
5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.91 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.66 g, 81%) following general procedure C. N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (1309, 69%) was prepared from 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
- ORD 기록
- ord-867e53abdefb422fa7a085d135247e2b
- 출처 데이터셋
- uspto-grants-2008_06
- 특허 번호
- US07384967B2
연결된 노트
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