Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-(2,4-Dichlorophenoxy)-5-fluoro-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,4-Dichlorophenol | HCID 8449 | — |
| 반응물 | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| 반응물 | 2-(2,4-Dichlorophenoxy)-5-fluoroaniline | HCID 29780019 | — |
| 생성물 | N-[2-(2,4-Dichlorophenoxy)-5-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 59733141 | 76% |
| 생성물 | 2-(2,4-Dichlorophenoxy)-5-fluoro-1-nitrobenzene | HCID 66998830 | 78% |
반응 단계
2-(2,4-Dichlorophenoxy)-5-fluoro-1-nitrobenzene (1.17 g, 78%) was prepared from 2,4-dichlorophenol (0.89 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,4-dichlorophenoxy)-5-fluoroaniline (0.68 g, 64%) following the general procedure B. N-[2-(2,4-Dichlorophenoxy)-5-fluorophenyl]-N′-(thiazol-2-yl)urea (150 mg, 76%) was prepared from 2-(2,4-dichlorophenoxy)-5-fluoroaniline (135 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384967B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-cf32d44bded3435f96290502ea4de892 |
| 출처 메모 | uspto-grants-2008_06 |