Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 반응물 | 1,2-Dichloro-4-fluoro-5-nitrobenzene | HCID 533951 | — |
| 반응물 | 4,5-Dichloro-2-(2,3-dimethoxyphenoxy)aniline | HCID 66998926 | — |
| 생성물 | N-[4,5-Dichloro-2-(2,3-dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732851 | 62% |
| 생성물 | 4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene | HCID 66999020 | 65% |
반응 단계
4,5-Dichloro-2-(2,3-dimethoxyphenoxy)-1-nitrobenzene (1.12 g, 65%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 4,5-dichloro-2-fluoro-1-nitrobenzene (1.05 g, 5.0 mmol) following the general procedure A. This was reduced to 4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline (0.68 g, 67%) following general procedure B. N-[4,5-Dichloro-2-(2,3-dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (136 mg, 62%) was prepared from 4,5-dichloro-2-(2,3-dimethoxyphenoxy)aniline (157 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384967B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-1ebab1e7ed644aa6ab9cf9db4f7b7ca8 |
| 출처 메모 | uspto-grants-2008_06 |