Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 4-(Azidomethyl)-2-thiazolamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 4-Chloromethylthiazol-2-ylamine | HCID 73229 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 4-(Azidomethyl)-2-thiazolamine | HCID 53416578 | 70% |
반응 단계
To a solution of 4-chloromethyl-thiazol-2-ylamine (7.45 g, 50.0 mmol) in dioxane:water mixture (8:2) was added sodium azide (4.87 g, 75.0 mmol) and the reaction mixture was refluxed for 2–3 h. The mixture was concentrated in vacuo to remove all dioxane and the residue was dissolved in EtOAc (200 mL). The organic layer was washed with water (2×200 mL), brine (2×200 mL), dried over (Na2SO4) and concentrated in vacuo to give 4-azidomethyl-thiazol-2-ylamine in 70–90% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384967B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-682e7436e7f94a988d8ac2be814ac265 |
| 출처 메모 | uspto-grants-2008_06 |