Methyl 3-mercaptopropionate → 3-(2-Amino-thiazol-4-ylmethylsulfanyl)-propionic acid methyl ester

반응식

Cl[CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1.[CH3:9][O:10][C:11](=[O:15])[CH2:12][CH2:13][SH:14]>>[CH3:9][O:10][C:11](=[O:15])[CH2:12][CH2:13][S:14][CH2:2][C:3]1[N:4]=[C:5]([NH2:8])[S:6][CH:7]=1

참가 물질

반응물 2

HCID 18050Methyl 3-mercaptopropionate

HCID 732294-Chloromethylthiazol-2-ylamine

생성물 1

HCID 436176263-(2-Amino-thiazol-4-ylmethylsulfanyl)-propionic acid methyl ester수율 60%

실험 절차

3-(2-Amino-thiazol-4-ylmethylsulfanyl)-propionic acid methyl ester (0.75 g, 60%) was prepared from 4-chloromethyl-thiazol-2-ylamine (1.00 g, 5.41 mmol) and 3-mercapto-propionic acid methyl ester (0.97 g, 8.11 mmol) according to procedure Z.

출처 및 근거

ORD 기록: ord-0a65a01ed6e8487db7b8cbbd99ffa4af
출처 데이터셋: uspto-grants-2008_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07384967B2

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