2-Aminothiazole → HCID 59732812, 화합물

HRID 131954

반응식

HRID 131954 반응식
[O:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][OH:8].F[C:10]1[CH:11]=[C:12]([CH3:19])[CH:13]=[CH:14][C:15]=1[N+:16]([O-:18])=[O:17].[CH3:20][C:21]1[CH:27]=[CH:26][C:24]([NH2:25])=[C:23]([O:28][CH2:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][O:31]2)[CH:22]=1.[NH2:36][C:37]1[S:38][CH:39]=[CH:40][N:41]=1>>[N+:16]([C:15]1[CH:14]=[CH:13][C:12]([CH3:19])=[CH:11][C:10]=1[O:8][CH2:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][O:1]1)([O-:18])=[O:17].[CH3:20][C:21]1[CH:27]=[CH:26][C:24]([NH:25][C:7]([NH:36][C:37]2[S:38][CH:39]=[CH:40][N:41]=2)=[O:8])=[C:23]([O:28][CH2:29][CH:30]2[CH2:35][CH2:34][CH2:33][CH2:32][O:31]2)[CH:22]=1

참가 물질

6

반응물 4

HCID 21552-AminothiazoleHCID 7524Tetrahydropyran-2-methanolHCID 67966Benzene, 2-fluoro-4-methyl-1-nitro-HCID 435916984-Methyl-2-(tetrahydro-2H-pyran-2-ylmethoxy)-phenylamine2회

생성물 2

HCID 59732812HCID 59732812, 화합물수율 71%HCID 66999100Tetrahydro-2-[(5-methyl-2-nitrophenoxy)methyl]-2H-pyran수율 64%

실험 절차

4-Nitro-3-(tetrahydro-pyran-2-ylmethoxy)-toluene (0.80 g, 64%) was prepared from tetrahydropyran-2-ylmethanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (0.50 g, 71%) following general procedure C. 1-[4-Methyl-2-(tetrahydro-pyran-2-ylmethoxy)-phenyl]-3-thiazol-2-yl-urea (246 mg, 71%) was prepared from 4-methyl-2-(tetrahydro-pyran-2-ylmethoxy)-aniline (221 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

출처 및 근거

ORD 기록
ord-a090687728db4285b47d902fd4b8279d
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384967B2

연결된 노트

불러오는 중…