Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | — |
| 반응물 | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| 반응물 | 5-Formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline | HCID 86593084 | — |
| 생성물 | 1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea | HCID 59732954 | 69% |
| 생성물 | 4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde | HCID 86593083 | 70% |
반응 단계
4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde (1.0 g, 70%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.84 g, 5.0 mmol) following the general procedure A. This was reduced to 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (0.57 g, 62%) following general procedure B. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea (265 mg, 69%) was prepared from 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (261 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384967B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-971efa14457b47c499e8f06cd1911d93 |
| 출처 메모 | uspto-grants-2008_06 |