2-Aminothiazole → 4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde

HRID 131973

반응식

HRID 131973 반응식
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[OH:10].F[C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][C:13]=1[N+:20]([O-:22])=[O:21].[CH:23]([C:25]1[CH:26]=[CH:27][C:28]([O:32][C:33]2[C:38]([O:39][CH3:40])=[CH:37][CH:36]=[CH:35][C:34]=2[F:41])=[C:29]([CH:31]=1)[NH2:30])=[O:24].[NH2:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH3:9])[C:3]=1[O:10][C:12]1[CH:19]=[CH:18][C:15]([CH:16]=[O:17])=[CH:14][C:13]=1[N+:20]([O-:22])=[O:21].[F:41][C:34]1[CH:35]=[CH:36][CH:37]=[C:38]([O:39][CH3:40])[C:33]=1[O:32][C:28]1[CH:27]=[CH:26][C:25]([CH:23]=[O:24])=[CH:31][C:29]=1[NH:30][C:3]([NH:42][C:43]1[S:44][CH:45]=[CH:46][N:47]=1)=[O:10]

참가 물질

6

반응물 4

HCID 21552-AminothiazoleHCID 5981294-Fluoro-3-nitrobenzaldehydeHCID 27373672-Fluoro-6-methoxyphenolHCID 865930845-Formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline2회

생성물 2

HCID 597329541-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea수율 69%HCID 865930834-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde수율 70%

실험 절차

4-(2-Fluoro-6-methoxy-phenoxy)-3-nitrobenzaldehyde (1.0 g, 70%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.84 g, 5.0 mmol) following the general procedure A. This was reduced to 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (0.57 g, 62%) following general procedure B. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-5-formyl-phenyl]-3-thiazol-2-yl-urea (265 mg, 69%) was prepared from 5-formyl-2-(2-fluoro-6-methoxy-phenoxy)-aniline (261 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.

출처 및 근거

ORD 기록
ord-971efa14457b47c499e8f06cd1911d93
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384967B2

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