Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → Tolperisone Hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1,3-Dioxolane | HCID 12586 | — |
| 반응물 | p-Methylpropiophenone | HCID 21429 | — |
| 반응물 | Piperidine, hydrochloride (1:1) | HCID 2723721 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | Tolperisone Hydrochloride | HCID 92965 | — |
반응 단계
75 kg piperidine hydrochloride and 105 kg 4-methylpropiophenone are heated to 90° C. with 180 kg of 1,3-dioxolane and 12 kg of hydrochloric acid under a nitrogen atmosphere for 7 to 20 hours. With addition of 500 kg of ethyl acetate and 440 kg MTBE at a temperature in the range of (40-80° C.), a suspension of the product is produced. After that the solid is separated from the liquid as a damp product and then dried at 60-80° C. in the vacuum oven (200-500 mbar) over a period of 12-24 hours whereby 140 kg (81.5%) of colorless crystals are isolated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07385060B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-bc1689beeb9d4730bb23488d2b6ff9ca |
| 출처 메모 | uspto-grants-2008_06 |