Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diiodomethane → 4-[1-(3,4-Dimethylphenoxymethyl)-1H-benzimidazol-2-yl]-furazan-3-yl-N-(2-cyanoethyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diiodomethane | HCID 6346 | — |
| 반응물 | 3,4-Dimethylphenol | HCID 7249 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-[4-(1H-Benzoimidazol-2-yl)-furazan-3-ylamino]-propionitrile | HCID 136389313 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-[1-(3,4-Dimethylphenoxymethyl)-1H-benzimidazol-2-yl]-furazan-3-yl-N-(2-cyanoethyl)-amine | HCID 67463629 | — |
반응 단계
A suspension of 4-(1H-benzimidazol-2-yl)-furazan-3-yl-N-(2-cyanoethyl)-amine (0.15 g, 0.59 mmol, Example 6a), potassium carbonate (0.325 g, 2.36 mmol), diiodomethane (0.16 g, 0.59 mmol) and 3,4-dimethylphenol (0.072 g, 0.59 mmol) in DMF (5 ml) is stirred at room temperature for 16 hours. The reaction mixture is diluted with ethyl acetate, washed with water and dried over sodium sulphate. Filtration of the sodium sulphate, concentration of the filtrate under reduced pressure and chromatography of the residue on silicagel using hexane-ethyl acetate as eluent gives the title compound as a yellowish solid, m.p. 132-135° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07385061B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-32189c7fc33341d3ba13f3040b35987d |
| 출처 메모 | uspto-grants-2008_06 |