1,2-Dichloroethane → HCID 178470495, 화합물

HRID 132047

반응식

HRID 132047 반응식
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=O.[CH2:12]([O:14][C:15]([C:17]1[C:21]([NH2:22])=[CH:20][NH:19][N:18]=1)=[O:16])[CH3:13].C(Cl)CCl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C.O>[CH2:12]([O:14][C:15]([C:17]1[C:21]([NH:22][C:4](=[O:6])[C:3]2[C:7]([F:11])=[CH:8][CH:9]=[CH:10][C:2]=2[F:1])=[CH:20][NH:19][N:18]=1)=[O:16])[CH3:13]

참가 물질

7

반응물 4

HCID 111,2-DichloroethaneHCID 97962,6-Difluorobenzoic acidHCID 757711-HydroxybenzotriazoleHCID 178470494HCID 178470494, 화합물

생성물 1

HCID 178470495HCID 178470495, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2,6-difluorobenzoic acid (6.32 g, 40.0 mmol), 4-amino-1H-pyrazole-3-carboxylic acid ethyl ester (5.96 g, 38.4 mmol), EDC (8.83 g, 46.1 mmol) and HOBt (6.23 g, 46.1 mmol) in DMF (100 ml) was stirred at ambient temperature for 6 h. The mixture was reduced in vacuo, water added and the solid formed collected by filtration and air-dried to give 4-(2,6-difluoro-benzoylamino)-1H-pyrazole-3-carboxylic acid ethyl ester as the major component of a mixture (15.3 g). (LC/MS: Rt 3.11, [M+H]+295.99).

후처리

  1. additionadded
  2. customthe solid formed
  3. filtrationcollected by filtration
  4. customair-dried

출처 및 근거

ORD 기록
ord-fab86eb499d149f49db13fbbf577861d
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07385059B2

연결된 노트

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