Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanolamine → (S)-N-{3-Cyclohexyl-1-[2-(5-benzyloxy-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-propyl}-3-methoxy-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | m-Anisoyl chloride | HCID 74374 | — |
| 반응물 | 5-(Benzyloxy)-2,3-dihydro-1H-indole | HCID 16794881 | — |
| 반응물 | (S)-2-amino-4-cyclohexylbutanoic acid | HCID 22839041 | — |
| 생성물 | (S)-N-{3-Cyclohexyl-1-[2-(5-benzyloxy-2,3-dihydro-indol-1-yl)-ethylcarbamoyl]-propyl}-3-methoxy-benzamide | HCID 11444487 | 10% |
반응 단계
Following the procedures of Example 3, except using m-anisoyl chloride, (S)-2-amino-4-cyclohexyl-butyric acid, ethanolamine and 5-benzyloxyindoline as starting materials, the title compound was prepared in 10% yield. The final material was purified by reverse phase preparative HPLC using TFA as a modifier. The final compound is therefore a partial TFA salt: HPLC-MS calcd. for C35H43N3O4 (M+H+) 570.3, found 570.6.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07384970B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-b7d77f068c1441a08b4c05fbe9673a44 |
| 출처 메모 | uspto-grants-2008_06 |