반응 단계
This material was prepared in 92% yield in an analogous fashion to example 158 except that 3-(S)-(2-(S)-Benzyloxycarbonylamino-4,4-dimethyl-pentanoylamino)-4-(5-fluoro-2,3-dihydro-indol-1-yl)-butyric acid tert-butyl ester was deprotected and m-anisic acid was used as the acid; 1H NMR (CDCl3, 400 MHz) δ 0.95 (s, 9H), 1.40 (s, 9H), 1.57 (dd, 1H, J1=8.5, J2=14.5), 1.88 (dd, 1H, J1=4.0, J2=14.5), 2.51 (dd, 1H, J1=5.9, J2=16.3), 2.61 (dd, 1H, J1=5.1, J2=16.3), 2.81-2.96 (m, 2H), 3.07 (dd, 1H, J1=7.4, J2=13.8), 3.22 (dd, 1H, J1=6.5, J2=13.8), 3.34 (dd, 1H, J1=8.5, J2=17.1), 3.44 (dd, 1H, J=8.6, J2=16.3), 3.82 (s, 3H), 4.34-4.43 (m, 1H), 4.64 (ddd, 1H, J=4.0, J2=J3=8.5), 6.39 (dd, 1H, J=4.1, J2=8.5), 6.57 (d, 1H, J=8.4), 6.66-6.75 (m, 1H), 6.73-6.78 (m, 1H), 6.97 (d, 1H, J=8.5), 6.98-7.04 (m, 1H), 7.23-7.33 (m, 3H); HPLC-MS calcd. for C31H42FN3O5 (M+H+) 556.3, found 556.5.
