p-Toluenesulfonic acid monohydrate → (S)-2-(4-bromo-8-oxo-6,7,8,10-tetrahydro-3H-oxepino[3,4-e]indazol-7-yl)acetic acid

HRID 132456노트

반응식

HRID 132456 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH2:13][C@@H:14]([CH2:18][C:19]([OH:21])=[O:20])[C:15]([OH:17])=[O:16])[C:5]([CH2:11]O)=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:10]2[NH:9][N:8]=[CH:7][C:6]=2[C:5]2[CH2:11][O:16][C:15](=[O:17])[C@H:14]([CH2:18][C:19]([OH:21])=[O:20])[CH2:13][C:4]=2[CH:3]=1

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 59732086(S)-2-((7-bromo-4-(hydroxymethyl)-1H-indazol-5-yl)methyl)succinic acid

생성물 1

HCID 59732081(S)-2-(4-bromo-8-oxo-6,7,8,10-tetrahydro-3H-oxepino[3,4-e]indazol-7-yl)acetic acid수율 99%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

(S)-2-((7-Bromo-4-(hydroxymethyl)-1H-indazol-5-yl)methyl)succinic acid (95 mg, 0.266 mmol) was suspended in toluene (15 mL). p-Toluenesulfonic acid monohydrate (3.5 mg, 0.018 mmol) was added to the mixture. Reaction was warmed to reflux and held with stirring for 18 hours. Mixture was concentrated to dryness. Title compound was obtained as tan solid in 99% yield. LCMS (M−H)−=339.0, 337.0.

후처리

  1. customReaction
  2. temperaturewas warmed
  3. temperatureto reflux
  4. concentrationMixture was concentrated to dryness

출처 및 근거

ORD 기록
ord-7922d22c3ede4e3e9509e4effb10b728
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07384931B2

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