[4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine → 2-Chloro-N-{5-[2-(4-fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-acetamide

참여 물질

역할	이름	HCID	투입량
반응물	[4-(2-Amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine	HCID 9857535	—
반응물	2-Chloro-N-{4-methyl-5-[2-(3-nitro-phenylamino)-pyrimidin-4-yl]-thiazol-2-yl}-acetamide	HCID 10179394	—
생성물	2-Chloro-N-{5-[2-(4-fluoro-phenylamino)-pyrimidin-4-yl]-4-methyl-thiazol-2-yl}-acetamide	HCID 9969870	—

반응 단계

This compound was prepared from [4-(2-amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-fluoro-phenyl)-amine in a manner analogous to that described above for compound [60]. 1H-NMR (DMSO-d6) δ: 2.94 (s, 3H, CH3), 4.75 (s, 2H, CH2), 7.44 (m, 3H, pyrimidinyl-H & Ph-H), 8.09 (m, 2H, Ph-H), 8.28 (s, 1H, NH), 8.80 (d, 1H, J=5.2 Hz, pyrimidinyl-H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07388015B2
출처 데이터셋	uspto-grants-2008_06
ORD ID	ord-3612321ff95b440a989d2da6440f491f
출처 메모	uspto-grants-2008_06