Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Nitrophenol → 1-(Benzhydryloxy)-2-nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Nitrophenol | HCID 6947 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Bromodiphenylmethane | HCID 236603 | — |
| 반응물 | Potassium | HCID 5462222 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 1-(Benzhydryloxy)-2-nitrobenzene | HCID 7434122 | 39.5% |
반응 단계
A mixture of o-nitrophenol (2.08 g, 15.0 mmol), 1-[bromo(phenyl)methyl]benzene (3.70 g, 15.0 mmol) and potassium carbonated (K2CO3) (4.14 g, 30.0 mmol) in acetone (60 mL) was kept at reflux temperature for 5 h. The reaction mixture was cooled to room temperature, concentrated in vacuo. The residue was partitioned between dichloromethane (CH2Cl2) and water (H2O), organic layer dried over sodium sulphate (Na2SO4), filtered, concentrated. The residue was purified by silica gel flash chromatography to give subtitled compound (1.81 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07388020B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-079031298525448db5b6e52e03b4a7e2 |
| 출처 메모 | uspto-grants-2008_06 |