HCID 68527883, 화합물 → HCID 68527407, 화합물

HRID 132611

반응식

HRID 132611 반응식
O[C:2]1([C:7]2[CH:8]=[C:9]([CH:32]=[CH:33][CH:34]=2)[O:10][C:11]2[C:16]([NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)=[O:19])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:6][CH:5]=[CH:4][CH2:3]1.OC(C1C=C(C=CC=1)OC1C(NC(NC2C=CC(OC(F)(F)F)=CC=2)=O)=CC=CN=1)(CC=C)CC=C>CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C=CC=CC=3)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1.C1CCC(P(C2CCCCC2)C2CCCCC2)CC1.ClCCl>[CH:2]1([C:7]2[CH:8]=[C:9]([CH:32]=[CH:33][CH:34]=2)[O:10][C:11]2[C:16]([NH:17][C:18]([NH:20][C:21]3[CH:26]=[CH:25][C:24]([O:27][C:28]([F:31])([F:30])[F:29])=[CH:23][CH:22]=3)=[O:19])=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3]1

참가 물질

5

반응물 2

HCID 68527883HCID 68527883, 화합물HCID 68529786HCID 68529786, 화합물

생성물 1

HCID 68527407HCID 68527407, 화합물

시약·촉매·용매 2

HCID 11147261(1,3-Dimesitylimidazolidin-2-ylidene)(tricyclohexylphosphine)benzylidene ruthenium dichloride촉매2회HCID 6344Dichloromethane용매

실험 절차

1-(2-(3-(1-hydroxycyclopent-3-enyl)phenoxy)pyridin-3-yl)-3-(4-(trifluoromethoxy)phenyl)urea: A mixture of Example 640 (125 mg, 0.25 mmol) and Grubb's second generation catalyst (0.6 mg) in dichloromethane (70 mL) was stirred at rt for 16 h. An additional 1.0 mg of Grubb's second generation catalyst was added and the mixture was stirred at rt for an additional 17 h. Evaporation under reduced pressure afforded a residue which was filtered and purified using reverse-phase preparative HPLC. (M+H)+=472.

후처리

  1. customEvaporation under reduced pressure
  2. customafforded a residue which
  3. filtrationwas filtered
  4. custompurified

출처 및 근거

ORD 기록
ord-4f0a761f324e433fad2366a03414ca74
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388021B2

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