3-Bromobenzonitrile → 3-(6-(1-Acetyl-pyrrolidin-2-yl)-2-pyridin-2-yl-1H-benzimidazol-5-yloxy)-benzonitrile

HRID 13269

반응식

HRID 13269 반응식
[OH:1][C:2]1[C:3]([CH:25]2[CH2:29][CH2:28][CH2:27][N:26]2[C:30](=[O:32])[CH3:31])=[CH:4][C:5]2[N:9](COCC[Si](C)(C)C)[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)=[N:7][C:6]=2[CH:24]=1.[C:33]([C:35]1[CH:36]=[C:37](Br)[CH:38]=[CH:39][CH:40]=1)#[N:34]>>[C:30]([N:26]1[CH2:27][CH2:28][CH2:29][CH:25]1[C:3]1[C:2]([O:1][C:39]2[CH:40]=[C:35]([CH:36]=[CH:37][CH:38]=2)[C:33]#[N:34])=[CH:24][C:6]2[N:7]=[C:8]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[NH:9][C:5]=2[CH:4]=1)(=[O:32])[CH3:31]

참가 물질

3

반응물 2

HCID 233813-BromobenzonitrileHCID 231452771-(2-(6-hydroxy-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone

생성물 1

HCID 231451213-(6-(1-Acetyl-pyrrolidin-2-yl)-2-pyridin-2-yl-1H-benzimidazol-5-yloxy)-benzonitrile

실험 절차

The entitled compound was obtained as an oily substance in the same method as in Example 121 (step 11), (step 12) or in accordance with the method or by combining it with an ordinary method but using 1-(2-(6-hydroxy-2-pyridin-2-yl-3-(2-trimethylsilanyl-ethoxymethyl)-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone obtained in Example 121 (step 10) and 3-cyanobromobenzene.

후처리

  1. customThe entitled compound was obtained as an oily substance in the same method as in Example 121 (step 11), (step 12) or in accordance with the method

출처 및 근거

ORD 기록
ord-34f455e98852447aadb9e7dea234af3f
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

연결된 노트

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