Benzyl Bromide → 50984-08-2

HRID 132763노트

반응식

HRID 132763 반응식
C(=O)([O-])[O-].[K+].[K+].[O:7]=[C:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]([O:15][CH2:16][CH3:17])=[O:14].[CH2:18](Br)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CC(C)=O>[CH2:18]([C:9]1([C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:10][CH2:11][CH2:12][C:8]1=[O:7])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 69136Ethyl 2-oxocyclopentanecarboxylate

생성물 1

HCID 26669250984-08-2수율 66.9%

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

38.7 grams of anhydrous potassium carbonate and 90 ml of acetone were mixed, then with stirring, to the resulting mixture was dropwise added a solution of 10.4 ml of ethyl 2-oxocyclopentane carboxylate in 45 ml of acetone. After stirring at room temperature for 35 minutes, 16.7 ml of benzyl bromide was dropwise added thereto, and the reaction was allowed to continue under reflux for 3 hours. Then the reaction mixture was cooled to room temperature, filtered, concentrated, and distilled under reduced pressure. 11.54 g of colorless liquid as the second distillate cut was collected. Yield: 66.9%.

후처리

  1. stirringAfter stirring at room temperature for 35 minutes
  2. temperatureunder reflux for 3 hours
  3. filtrationfiltered
  4. concentrationconcentrated
  5. distillationdistilled under reduced pressure
  6. distillation11.54 g of colorless liquid as the second distillate cut was collected

출처 및 근거

ORD 기록
ord-e1d746ce33cf4926a7b7bfb2c0476103
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07388103B2

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