Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | 5-Hydroxyindole-2-carboxylic acid | HCID 88958 | — |
| 반응물 | [5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone | HCID 67527268 | — |
| 생성물 | (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone | HCID 44185244 | — |
반응 단계
In analogy to the procedure described for the synthesis of intermediate 1, step 4, the title compound was synthesized from 5-hydroxy-1H-indole-2-carboxylic acid (purchased at Fluka, Ref 55355) and morpholine. The desired product was obtained in 86% yield as white solid. MS (m/e): 493.1 (2M+, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07388095B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-3d1545c0174344af888da1f2167d0abb |
| 출처 메모 | uspto-grants-2008_06 |