Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone → {5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone | HCID 44185244 | — |
| 반응물 | 3-(3-Azabicyclo[3.1.0]hexan-3-yl)propan-1-ol | HCID 67527519 | — |
| 생성물 | {5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone | HCID 16754253 | — |
반응 단계
In analogy to the procedure described for the synthesis of example 1, step 1, the title compound was synthesized from (5-hydroxy-1H-indol-2-yl)-morpholin-4-yl-methanone (example 5, step 3) and 3-(3-aza-bicyclo[3.1.0]hex-3-yl)-propan-1-ol (example 5, step 2). The title product was obtained in 49% yield as white solid. MS (m/e): 370.5 (MH+, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07388095B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-3e3303021aa14bd39e263710560930e2 |
| 출처 메모 | uspto-grants-2008_06 |