2,2,2-Trifluoroethyl trifluoromethanesulfonate → [5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone

참여 물질

역할	이름	HCID	투입량
반응물	2,2,2-Trifluoroethyl trifluoromethanesulfonate	HCID 80366	—
반응물	{5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone	HCID 16754253	—
반응물	[5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone	HCID 67527268	—
생성물	[5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone	HCID 16112804	—

반응 단계

In analogy to the procedure described for the synthesis of intermediate 1, step 1, the title compound was synthesized from {5-[3-(3-aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone (Example 5, step 4) and 2,2,2-trifluoroethyl-trifluoromethanesulfonate. The title product was obtained in 45% yield as white solid. MS (m/e): 452.5 (MH+, 100%).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07388095B2
출처 데이터셋	uspto-grants-2008_06
ORD ID	ord-e70956c355d04fa79af0aaa0a047a06f
출처 메모	uspto-grants-2008_06