Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetamidine → 6-(tert-Butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetamidine | HCID 2776882 | — |
| 반응물 | tert-butyl 3-[(dimethylamino)methylene]-4-oxotetrahydro-1(2H)-pyridinecarboxylate | HCID 53395404 | — |
| 생성물 | 6-(tert-Butoxycarbonyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine | HCID 69223721 | — |
반응 단계
Reaction of tert-butyl 4-oxo-3-(dimethylaminomethylidene)-1-piperidinecarboxylate (1.78 g) from Intermediate 28, Step A with trifluoroacetamidine (0.86 g) according to the procedure described for Intermediate 28, Step B, and purification by flash chromatography (silica gel; 18% ethyl acetate/hexanes as eluant), afforded the title compound as a viscous orange oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07388019B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-d24fb42fea5d4d20997ff53e5906c7c3 |
| 출처 메모 | uspto-grants-2008_06 |