8-Methylquinoline → Quinoline, 8-methyl-, 1-oxide

HRID 133099

반응식

HRID 133099 반응식
ClC1C=CC=C(C(OO)=[O:9])C=1.[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N:21]=[CH:20][CH:19]=[CH:18]2>ClCCl>[CH3:12][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]2[C:22]=1[N+:21]([O-:9])=[CH:20][CH:19]=[CH:18]2

참가 물질

4

반응물 2

HCID 119108-MethylquinolineHCID 70297m-Chloroperbenzoic acid

생성물 1

HCID 12488418Quinoline, 8-methyl-, 1-oxide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 2.45 g of m-chloroperbenzoic acid in 15 ml of dichloromethane is added dropwise to a solution of 1 g of commercially available 8-methylquinoline in 15 ml of dichloromethane. The reaction mixture is stirred over night diluted with 30 ml of dichloremethane and extracted two times each with 50 ml of halfsaturated aqueous sodium hydrogencarbonate solution. The organic layer is dried over magnesium sulfate, filtered and evaporated in vacuo. The residue is chromatographed on silica gel (dichloromethane/methanol 98:2). 1 g of the title compound are obtained as colourless solid.

후처리

  1. additiondiluted with 30 ml of dichloremethane
  2. extractionextracted two times each with 50 ml of halfsaturated aqueous sodium hydrogencarbonate solution
  3. dry with materialThe organic layer is dried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated in vacuo
  6. customThe residue is chromatographed on silica gel (dichloromethane/methanol 98:2)

출처 및 근거

ORD 기록
ord-ad3c59b8ebdc4483b2bd12794794eebd
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390819B2

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