Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → Methyl 2-methyl-6-nitrobenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 6-Methyl-2-nitrobenzoic acid | HCID 16097 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Methyl 2-methyl-6-nitrobenzoate | HCID 596057 | — |
반응 단계
To a solution of the 2-methyl-6-nitro-benzoic acid (5.6 g, 30.9 mmol, 1.0 eq, Aldrich) and acetone (100 mL) was added crushed K2CO3 (21.4 g, 154.6 mmol, 5 eq) and MeI (9.6 mL, 154.6 mmol, 5.0 eq.). The reaction was heated to reflux for 15 h then cooled to RT, filtered and concentrated in vacuo. The filtrate was dissolved in EtOAc, washed with H2O and brine, dried (MgSO4) and concentrated in vacuo to give the desired compound as a reddish-brown oil which upon standing at RT crystallized as tan needles.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07390820B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-ca3edb7fbf8848eeaa728149acea2bb2 |
| 출처 메모 | uspto-grants-2008_06 |