1-methyl-1H-pyrazole-3-carboxylic acid → 5-(2,6-Difluoro-phenoxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

HRID 13317

반응식

HRID 13317 반응식
[F:1][C:2]1[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10](C3C=CC=CN=3)=[N:11][C:7]=2[CH:6]=1.[CH3:37][N:38]1[CH:42]=[CH:41][C:40](C(O)=O)=[N:39]1>>[F:1][C:2]1[CH:35]=[CH:34][CH:33]=[C:32]([F:36])[C:3]=1[O:4][C:5]1[C:19]([O:20][C:21]2[CH:22]=[N:23][C:24]([S:27]([CH2:30][CH3:31])(=[O:29])=[O:28])=[CH:25][CH:26]=2)=[CH:18][C:8]2[NH:9][C:10]([C:40]3[CH:41]=[CH:42][N:38]([CH3:37])[N:39]=3)=[N:11][C:7]=2[CH:6]=1

참가 물질

3

반응물 2

HCID 5731761-methyl-1H-pyrazole-3-carboxylic acidHCID 231453325-(2,6-Difluoro-phenoxy)-2-pyridin-2-yl-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

생성물 1

HCID 1355085165-(2,6-Difluoro-phenoxy)-2-(1-methyl-1H-pyrazol-3-yl)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-1H-benzimidazole

실험 절차

The entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method or by combining it with an ordinary method but using 4-(2,6-difluoro-phenoxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 235 and 1-methyl-1H-pyrazole-3-carboxylic acid.

후처리

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method

출처 및 근거

ORD 기록
ord-0c0f07842a0d498ebc83faf34377effb
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

연결된 노트

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