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Acetic Acid → 3-(3-Hydroxymethylphenyl)-1,6-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one

HRID 133188
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인쇄 미리보기

반응식

HRID 133188 반응식
[CH3:1][N:2]1[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH:5]=[C:4]([C:16]2[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=2)[CH:19]=[O:20])[C:3]1=[O:24])=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=3.CC(O)=O.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>C(Cl)Cl>[OH:20][CH2:19][C:18]1[CH:17]=[C:16]([C:4]2[C:3](=[O:24])[N:2]([CH3:1])[C:7]3[NH:8][C:9]4[C:14]([C:6]=3[CH:5]=2)=[CH:13][C:12]([CH3:15])=[CH:11][CH:10]=4)[CH:23]=[CH:22][CH:21]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 176Acetic AcidHCID 5049666Sodium triacetoxyborohydrideHCID 866023433-(1,6-Dimethyl-2-oxo-2,9-dihydro-1H-pyrido[2,3-b]-indol-3-yl)benzaldehyde

생성물 1

HCID 673870523-(3-Hydroxymethylphenyl)-1,6-dimethyl-1,9-dihydro-2H-pyrido[2,3-b]indol-2-one수율 71%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

280 mg of the compound obtained in Stage A are placed in 10 ml of CH2Cl2 and the minimum amount of AcOH to dissolve the compound, 375 mg of NaBH(OAc)3 are added and then the mixture is left stirring at AT for 18 hours. The reaction medium is evaporated and the residue is taken up in AcOEt and then filtration is carried out to produce 200 mg of the expected compound.

후처리

  1. additionare added
  2. waitthe mixture is left
  3. customThe reaction medium is evaporated
  4. filtrationfiltration

출처 및 근거

ORD 기록
ord-dd37dfd8276044ac8aeefb8ec0f2bc04
출처 데이터셋
uspto-grants-2008_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07390818B2

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