Cesium carbonate → 5-(N-Boc-Amino)-7-(3,3-dimethyl-butanonyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	1-Chloropinacolone	HCID 83572	—
반응물	5-(N-Boc-amino)-5,7-dihydro-6H-dibez[b,d]azepin-6-one	HCID 11493548	—
용매	Dimethylformamide	HCID 6228	—
용매	Dichloromethane	HCID 6344	—
생성물	5-(N-Boc-Amino)-7-(3,3-dimethyl-butanonyl)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one	HCID 86585173	—

반응 조건

온도	60 °C

반응 단계

A solution of 5-(N-Boc-amino)-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (0.2 g, 0.617 mmol) (Example 7-E) in DMF was treated with Cs2CO3 (0.3 g, 0.925 mmol) and warmed to 60° C. To the reaction mixture was added 1-chloro-3,3-dimethyl-2-butanone (0.096 ml, 0.74 mmol) (Aldrich) and stirring continued for 17 h. After cooling to 23° C., the mixture was diluted with CH2Cl2, washed with several portions of brine and dried over Na2SO4. The title compound was isolated as a colorless solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07390801B2
출처 데이터셋	uspto-grants-2008_06
ORD ID	ord-d1fa3de3d2de4dfd9b255070cd852129
출처 메모	uspto-grants-2008_06