참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 반응물 | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| 반응물 | 6-(Methylsulfonyl)pyridin-3-ol | HCID 23145196 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2,3-Difluoro-1-(6-methanesulfonyl-pyridin-3-yloxy)-4-nitro-benzene | HCID 23145796 | — |
반응 단계
112 mg of 6-methanesulfonyl-pyridin-3-ol and 100 mg of potassium carbonate were added to an N-methylpyrrolidinone (3 ml) solution of 135 mg of 2,3,4-trifluoro-nitrobenzene, and the reaction liquid was stirred at 50° C. for 1 hour. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1) to obtain the entitled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07728025B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_06 |
|---|
| ORD ID | ord-f1e825910c5e4810ac501736dcd3ce56 |
|---|
| 출처 메모 | uspto-grants-2010_06 |
|---|
