Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl pyruvate → N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl pyruvate | HCID 11748 | — |
| 반응물 | 1,3-Benzodioxol-5-amine | HCID 84310 | — |
| 반응물 | N-(3,4-methylenedioxyphenyl)alanine methyl ester | HCID 54531586 | — |
| 용매 | Isobutanol | HCID 6560 | — |
| 생성물 | N-(3,4-methylenedioxyphenyl)alanine Iso-butyl Ester | HCID 54134455 | — |
반응 단계
Following reductive amination General Procedure AA above and using 3,4-methylenedioxyaniline (Aldrich) and methyl pyruvate (Aldrich), N-(3,4-methylenedioxyphenyl)alanine methyl ester was prepared. The methyl ester was then transesterified following General Procedure AQ above and using iso butanol to provide the title compound as an oil. The reaction was monitored by silica gel dc (Rf=0.61 in 25% EtOAc/hexanes). Purification was by preparative plate chromatography with silica gel using 25% EtOAc/hexanes as the eluant.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07390801B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-12e04e799171427d96503c1f1f1c2440 |
| 출처 메모 | uspto-grants-2008_06 |