L-Alanine → N-[(2-naphthyl)acetyl]-L-alanine Iso-butyl Ester

HRID 133358

반응식

HRID 133358 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][C@H:16]([C:18]([OH:20])=[O:19])[CH3:17]>>[CH2:1]([O:19][C:18](=[O:20])[C@H:16]([CH3:17])[NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH:2]([CH3:11])[CH3:3]

참가 물질

3

반응물 2

HCID 5950L-AlanineHCID 113932-Naphthaleneacetic acid

생성물 1

HCID 15481768N-[(2-naphthyl)acetyl]-L-alanine Iso-butyl Ester

실험 절차

Following General Procedure BB and using 2-naphthylacetic acid (Aldrich) and L-alanine is iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 128°-129° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

후처리

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. extractionwas by extraction with Et2O

출처 및 근거

ORD 기록
ord-b6ffa61a8c7b4a9cb5f26d2206c05357
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390801B2

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