Potassium Cyanide → 4-Phenylbenzoylacetonitrile

HRID 133477노트

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HRID 133477 반응식
[C-:1]#[N:2].[K+].Br[CH2:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:10][CH:9]=1)=[O:7]>O.CC#N>[C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:12]=[CH:13][C:8]([C:6](=[O:7])[CH2:5][C:1]#[N:2])=[CH:9][CH:10]=1

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 672821-(1,1'-Biphenyl)-4-yl-2-bromoethanone

생성물 1

HCID 126868534-Phenylbenzoylacetonitrile수율 118.6%

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

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온도
50 °C

실험 절차

To a solution of 105 mg (1.6 mmol) of KCN in 1 mL of water, 220 mg (0.8 mmol) of 2-bromo-4′-phenylacetophenone in 3 mL of MeCN was added. The mixture was warmed in a 50° C. bath to dissolve some of the halide. After ˜20 min the solids dissolved. The reaction was stirred for 30 min, then partitioned between 1.2 N HCl and EtOAc. The organic layer was washed with brine, dried and concentrated leaving 210 mg of the title compound which was used in the next step without purification.

후처리

  1. dissolutionAfter ˜20 min the solids dissolved
  2. custompartitioned between 1.2 N HCl and EtOAc
  3. washThe organic layer was washed with brine
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-938f7efe1b624dd0a6560a4a80aeb9bc
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390835B2

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