Sodium Methoxide → HCID 67482916, 화합물

HRID 13351

반응식

HRID 13351 반응식
C[O-].[Na+].C([O:7][C@@H:8]1[CH2:12][N:11]([C:13](=[O:15])[CH3:14])[C@@H:10]([C:16]2[C:30]([O:31][C:32]3[CH:37]=[CH:36][C:35]([S:38]([CH3:41])(=[O:40])=[O:39])=[CH:34][CH:33]=3)=[CH:29][C:19]3[N:20]=[C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)[NH:22][C:18]=3[CH:17]=2)[CH2:9]1)(=O)C>CO>[OH:7][C@@H:8]1[CH2:12][N:11]([C:13](=[O:15])[CH3:14])[C@@H:10]([C:16]2[C:30]([O:31][C:32]3[CH:33]=[CH:34][C:35]([S:38]([CH3:41])(=[O:39])=[O:40])=[CH:36][CH:37]=3)=[CH:29][C:19]3[N:20]=[C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=4)[NH:22][C:18]=3[CH:17]=2)[CH2:9]1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 67483003trans-1-(4-acetoxy-2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone

생성물 1

HCID 67482916HCID 67482916, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

0.015 ml of 25% sodium methoxide was added to a methanol (2 ml) solution of 40 mg of trans-1-(4-acetoxy-2-(6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidin-1-yl)-ethanone obtained in Example 325, and the reaction liquid was stirred at room temperature for 10 minutes. The solvent was evaporated away under reduced pressure, and the residue was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid]. The solvent of the resulting fraction was diluted with ethyl acetate, washed with aqueous saturated sodium bicarbonate, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure to obtain the entitled compound as a white solid.

후처리

  1. customthe reaction liquid
  2. customThe solvent was evaporated away under reduced pressure
  3. customthe residue was purified through reversed-phase middle-pressure liquid chromatography [ODS-AS-360-CC (by YMC), mobile phase: water-acetonitrile-0.1% trifluoroacetic acid]
  4. additionThe solvent of the resulting fraction was diluted with ethyl acetate
  5. washwashed with aqueous saturated sodium bicarbonate
  6. dry with materialdried with anhydrous sodium sulfate
  7. customThe solvent was evaporated away under reduced pressure

출처 및 근거

ORD 기록
ord-47517cd23cb843e58edb72042e6fbf46
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

연결된 노트

불러오는 중…