1,1,1-Trifluoro-2,4-pentanedione → 2,2,2-Trifluoro-1-(6-methyl-4-phenyl-thieno[2,3-b]pyridin-5-yl)-ethanone

참여 물질

역할	이름	HCID	투입량
반응물	1,1,1-Trifluoro-2,4-pentanedione	HCID 73943	—
반응물	(2-Aminothiophen-3-yl)(phenyl)methanone	HCID 644720	—
촉매	Sulfuric Acid	HCID 1118	—
용매	Acetic Acid	HCID 176	—
생성물	2,2,2-Trifluoro-1-(6-methyl-4-phenyl-thieno[2,3-b]pyridin-5-yl)-ethanone	HCID 11652688	17%

반응 조건

온도	100 °C

반응 단계

To a stirred solution of 50 mg (0.24 mmol) (2-amino-thiophen-3-yl)-phenyl-methanone in 2 ml acetic acid was added 0.031 ml (0.24 mmol) of 1,1,1-trifluoro-pentane-2,4-dione and one drop of sulfuric acid. The mixture was then stirred at 100° C. for 10 minutes in a microwave and then concentrated in vacuo. Preparative HPLC (30% CH3CN/H20) afforded 13 mg (17%) 2,2,2-trifluoro-1-(6-methyl-4-phenyl-thieno[2,3-b]pyridin-5-yl)-ethanone as a yellow oil. ES-MS m/e (%): 322 (M+H+, 100).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07390903B2
출처 데이터셋	uspto-grants-2008_06
ORD ID	ord-fe41fcf64da04855b16fce2bcf085606
출처 메모	uspto-grants-2008_06