Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 133629생성일: 2026년 10월 26일
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → 1-(4-Chlorobenzyl)-3-[(4-benzoylbutyryl)amino]homopiperidine
https://huagongshe.com/reaction/133629
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 반응물 | delta-Oxobenzenepentanoic acid | HCID 73914 | — |
| 반응물 | 1-Hydroxybenzotriazole | HCID 75771 | — |
| 반응물 | 3-Amino-1-(4-chlorobenzyl)homopiperidine | HCID 18426239 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-(4-Chlorobenzyl)-3-[(4-benzoylbutyryl)amino]homopiperidine | HCID 9823008 | — |
반응 단계
EDCI (23 mg), HOBt (16.2 mg) and triethylamine (15.2 μL) were added to a chloroform (1 mL) solution of 3-amino-1-(4-chlorobenzyl)homopiperidine (24 mg, 0.10 mmol) and 4-benzoylbutyric acid (1.2 equivalents), and the resulting mixture was stirred at 25° C. for 16 hours. The reaction mixture was diluted with dichloromethane (0.5 mL), filtered through a PTFE membrane and concentrated to provide 1-(4-chlorobenzyl)-3-[(4-benzoylbutyryl)amino]homopiperidine (Compd. No. 994) (43 mg, 99%). The purity was determined by RPLC/MS (98%). ESI/MS m/e 413 (M++H, C24H29ClN2O2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07390830B1 |
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| 출처 데이터셋 | uspto-grants-2008_06 |
|---|
| ORD ID | ord-dba731bce0ea47c6ab606634cae1e2a4 |
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| 출처 메모 | uspto-grants-2008_06 |
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