(2R,4R)-2-amino-4-benzyl-4-hydroxyglutaric acid → 2-amino-4-benzyl-4-hydroxyglutaric Acid

HRID 133670

반응식

HRID 133670 반응식
[CH2:1]([C:8]([OH:19])([C:16]([OH:18])=[O:17])[CH2:9][C:10](=[N:14]O)[C:11]([OH:13])=[O:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H].N[C@H](C[C@@](CC1C=CC=CC=1)(O)C(O)=O)C(O)=O.N[C@@H](C[C@@](CC1C=CC=CC=1)(O)C(O)=O)C(O)=O>CO.N.[C].[Pd]>[NH2:14][CH:10]([CH2:9][C:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)([OH:19])[C:16]([OH:18])=[O:17])[C:11]([OH:13])=[O:12]

참가 물질

8

반응물 4

HCID 10354897(2R,4R)-2-amino-4-benzyl-4-hydroxyglutaric acidHCID 858482324-Benzyl-4-hydroxy-2-hydroxyiminoglutaric acidHCID 86595816(2S,4R)-2-amino-4-benzyl-4-hydroxyglutaric acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 220564762-amino-4-benzyl-4-hydroxyglutaric Acid

시약·촉매·용매 3

HCID 178418390HCID 178418390, 화합물촉매HCID 222Ammonia용매HCID 887Methanol용매

실험 절차

0.25 g (0.94 mmol) of 4-benzyl-4-hydroxy-2-hydroxyiminoglutaric acid was dissolved in 10 ml of aqueous 50% methanol solution, to which 0.5 ml of aqueous 28% ammonia was added. 1.0 g of 5% palladium-carbon (50% hydrous product) was added, for reaction at ambient temperature and a hydrogen pressure of 7.7 atmospheres. 72 hours later, the catalyst was filtered off, and the reaction solution was concentrated to dryness, to obtain 0. 10 g (0.35 mmol) of the ammonium salt of (2S, 4S)/(2R, 4R)-2-amino-4-benzyl-4-hydroxyglutaric acid and 0.10 g (0.35 mmol) of the ammonium salt of (2R, 4S)/(2S, 4R)-2-amino-4-benzyl-4-hydroxyglutaric acid as a mixture.

후처리

  1. additionwas added
  2. filtration72 hours later, the catalyst was filtered off
  3. concentrationthe reaction solution was concentrated to dryness
  4. customto obtain 0

출처 및 근거

ORD 기록
ord-a2446b2ab25e49fe971e3a214de450a5
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390909B2

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