Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → Ethyl 3-(4-aminophenyl)-2-cyanoacrylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Ethyl cyanoacetate | HCID 7764 | — |
| 반응물 | Diethylamine | HCID 8021 | — |
| 반응물 | 4-Aminobenzaldehyde | HCID 11158 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 3-(4-aminophenyl)-2-cyanoacrylate | HCID 3540149 | 83.1% |
반응 단계
36 g (0.3 mol) of para-aminobenzaldehyde are suspended in 300 ml of ethanol. 33.9 g (0.3 mol) of ethyl cyanoacetate and a mixture of 0.375 ml of diethylamine and 1.125 ml of acetic acid, as catalyst, are added to the suspension. The reaction mixture is refluxed for 2 hours, left to cool and then crystallized. After separating out the crystals by filtration and drying, 53.9 g (83% yield) of ethyl 3-(4-aminophenyl)-2-cyanoacrylate are obtained in the form of orange-coloured crystals.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07390916B2 |
| 출처 데이터셋 | uspto-grants-2008_06 |
| ORD ID | ord-6fe060502bb841b5a49f1768c8a4f508 |
| 출처 메모 | uspto-grants-2008_06 |