Ethyl cyanoacetate → Ethyl 4-acetamido-alpha-cyanocinnamate

HRID 133688

반응식

HRID 133688 반응식
[C:1]([CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2].[C:9]([NH:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=O)=[CH:15][CH:14]=1)(=[O:11])[CH3:10].N1CCCCC1>C(O)C>[C:9]([NH:12][C:13]1[CH:20]=[CH:19][C:16]([CH:17]=[C:3]([C:1]#[N:2])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:15][CH:14]=1)(=[O:11])[CH3:10]

참가 물질

5

반응물 3

HCID 7764Ethyl cyanoacetateHCID 8082PiperidineHCID 739424-Acetamidobenzaldehyde

생성물 1

HCID 245851Ethyl 4-acetamido-alpha-cyanocinnamate수율 41.3%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A mixture of 33.9 g (0.3 mol) of ethyl cyanoacetate and 59.1 g (0.3 mol) of 4-acetamidobenzaldehyde in 300 ml of ethanol in the presence of 5 ml of piperidine is refluxed for 3 hours. The very viscous medium is diluted with 800 ml of hot ethanol. It is filtered while hot. The yellow solid obtained is washed with hot ethanol. After filtration and drying, 32 g (41% yield) of ethyl 3-(4-acetylaminophenyl)-2-cyanoacrylate are obtained in the form of a pale yellow powder.

후처리

  1. temperatureis refluxed for 3 hours
  2. filtrationIt is filtered while hot
  3. customThe yellow solid obtained
  4. washis washed with hot ethanol
  5. filtrationAfter filtration
  6. customdrying

출처 및 근거

ORD 기록
ord-0de7e36560a4413c9a7044cf947d16d7
출처 데이터셋
uspto-grants-2008_06
특허 번호
US07390916B2

연결된 노트

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