5-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazole → (2R)-1-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxylic acid methoxy-methyl-amide

HRID 13369노트

반응식

HRID 13369 반응식
C(OC(C1C=CC=CC=1O[C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[NH:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)=[N:15][C:11]=2[CH:10]=1)=O)C.[CH3:39][O:40][N:41]([CH3:49])[C:42](=[O:48])[C@H:43]1[CH2:47][CH2:46][CH2:45][NH:44]1>>[CH3:39][O:40][N:41]([CH3:49])[C:42]([C@H:43]1[CH2:47][CH2:46][CH2:45][N:44]1[C:9]1[C:23]([O:24][C:25]2[CH:30]=[CH:29][C:28]([S:31]([CH3:34])(=[O:33])=[O:32])=[CH:27][CH:26]=2)=[CH:22][C:12]2[N:13]=[C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=3)[NH:15][C:11]=2[CH:10]=1)=[O:48]

참가 물질

3

반응물 2

HCID 231451405-(2-Ethoxycarbonyl-phenoxy)-6-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-1H-benzimidazoleHCID 86619210(R)-N-methoxy-N-methylprolinamide

생성물 1

HCID 86619209(2R)-1-(6-(4-Methanesulfonyl-phenoxy)-2-pyridin-2-yl-3H-benzimidazol-5-yl)-pyrrolidine-2-carboxylic acid methoxy-methyl-amide

실험 절차

The entitled compound was obtained in the same method as in Example 15 or in accordance with the method or by combining it with an ordinary method but using 5-fluoro-4-(4-methanesulfonyl-phenoxy)-2-nitro-phenylamine obtained in Example 14, and (R)—N-methoxy-N-methylprolinamide.

후처리

  1. customThe entitled compound was obtained in the same method as in Example 15 or in accordance with the method

출처 및 근거

ORD 기록
ord-d23f453932ce467ab722914a811b2947
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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