Ethanol → HCID 178513350, 화합물

HRID 13378

반응식

HRID 13378 반응식
[OH:1][NH2:2].[F:3][C:4]1[CH:34]=[CH:33][CH:32]=[CH:31][C:5]=1[O:6][C:7]1[C:21]([O:22][C:23]2[CH:24]=N[C:26]([C:29]#[N:30])=[CH:27][CH:28]=2)=[CH:20][C:10]2[NH:11][C:12]([C:14]3[CH:19]=[N:18][CH:17]=[CH:16][N:15]=3)=[N:13][C:9]=2[CH:8]=1.[CH2:35](O)C>>[F:3][C:4]1[CH:34]=[CH:33][CH:32]=[CH:31][C:5]=1[O:6][C:7]1[C:21]([O:22][C:23]2[CH:24]=[CH:35][C:26]([C:29](=[NH:30])[NH:2][OH:1])=[CH:27][CH:28]=2)=[CH:20][C:10]2[NH:11][C:12]([C:14]3[CH:19]=[N:18][CH:17]=[CH:16][N:15]=3)=[N:13][C:9]=2[CH:8]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 787HydroxylamineHCID 231451425-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole

생성물 1

HCID 178513350HCID 178513350, 화합물

실험 절차

0.5 ml of hydroxyamine (50% aqueous solution) was added to an ethanol (0.5 ml) solution of 6.0 mg of 5-(2-fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-cyano-pyridin-3-yloxy)-1H-benzimidazole obtained in Example 252, and the reaction liquid was stirred at room temperature for 3 hours. Then, the solvent was evaporated away under reduced pressure to obtain the entitled compound as a pale yellow solid.

후처리

  1. customthe reaction liquid
  2. customThen, the solvent was evaporated away under reduced pressure

출처 및 근거

ORD 기록
ord-b65b6ca0e7964ffe9e5e5a80eef06ad7
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

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