2,4-Difluorobenzonitrile → 4-(2-Cyano-5-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

HRID 13380

반응식

HRID 13380 반응식
[C:1]([C:3]1[CH:36]=[CH:35][CH:34]=[C:33](F)[C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#[N:2].[F:38]C1C=C(F)C=CC=1C#N>>[C:1]([C:3]1[CH:36]=[CH:35][C:34]([F:38])=[CH:33][C:4]=1[O:5][C:6]1[C:14]2[N:13]=[C:12]([C:15]3[CH:20]=[N:19][CH:18]=[CH:17][N:16]=3)[NH:11][C:10]=2[CH:9]=[C:8]([O:21][C:22]2[CH:23]=[N:24][C:25]([S:28]([CH2:31][CH3:32])(=[O:30])=[O:29])=[CH:26][CH:27]=2)[CH:7]=1)#[N:2]

참가 물질

3

반응물 2

HCID 775452,4-DifluorobenzonitrileHCID 113182844-(2-Cyano-6-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

생성물 1

HCID 231457744-(2-Cyano-5-fluoro-phenoxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole

실험 절차

The entitled compound was obtained in the same method as in Example 438 (step 2) or in accordance with the method or by combining it with an ordinary method but using 4-hydroxy-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyrazin-2-yl-1H-benzimidazole obtained in Example 442 and 2,4-difluoro-benzonitrile.

후처리

  1. customThe entitled compound was obtained in the same method as in Example 438 (step 2) or in accordance with the method

출처 및 근거

ORD 기록
ord-66a93e76712942c3813a3be8630cacbb
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728025B2

연결된 노트

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