1,4-Dioxane hydrochloride → (3-Fluoro-4-pyrrolidin-2-ylphenyl)amine dihydrochloride
반응식
[ClH:1].O1CCOCC1.[NH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[CH2:19][CH2:18][CH2:17][N:16]2C(OC(C)(C)C)=O)=[C:11]([F:27])[CH:10]=1>C(OCC)(=O)C.CO>[ClH:1].[ClH:1].[F:27][C:11]1[CH:10]=[C:9]([NH2:8])[CH:14]=[CH:13][C:12]=1[CH:15]1[CH2:19][CH2:18][CH2:17][NH:16]1참가 물질
5
실험 절차
100 ml of 4 N hydrochloric acid-dioxane solution was added to a solution of 19 g of t-butyl 2-(4-amino-2-fluoro-phenyl)-pyrrolidine-1-carboxylate obtained in Example 338 (step 2) in a mixture of 50 ml of ethyl acetate and 50 ml of methanol, with cooling with ice, and the reaction liquid was stirred overnight at room temperature. The solvent was evaporated away under educed pressure to obtain the entitled compound as a white solid.
후처리
- temperaturewith cooling with ice
- customthe reaction liquid
- customThe solvent was evaporated away under educed pressure
출처 및 근거
- ORD 기록
- ord-b7e1e372bc744877a5daed6594f78177
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07728025B2
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