Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromoaniline → N-(4-bromophenyl)-5-methoxy-1,3-benzothiazol-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromoaniline | HCID 7807 | — |
| 반응물 | 2-Bromo-5-methoxybenzothiazole | HCID 22040525 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | N-(4-bromophenyl)-5-methoxy-1,3-benzothiazol-2-amine | HCID 7489958 | — |
반응 단계
The mixture containing 2-bromo-5-methoxybenzthiazole (1 eq), 4-Bromoaniline (2 eq) and disopropylethylamine was subjected to microwave in NMP at 220° C. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product. MS: MH+=335
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728010B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-02426daa880b45148c58ba484bdb01f2 |
| 출처 메모 | uspto-grants-2010_06 |