Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tert-butyl 4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylate → 4-{2-[(4-Bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tert-butyl 4-{2-[(4-bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylate | HCID 22041284 | — |
| 촉매 | Water | HCID 962 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | 4-{2-[(4-Bromophenyl)amino]-1-methylbenzimidazol-5-yloxy}pyridine-2-carboxylic acid | HCID 22040646 | — |
반응 단계
A solution of the product of step 7 in trifluoroacetic acid was treated with two drops of water at room temperature for 3-4 hours or until the reaction was determined to be complete by HPLC. The reaction was evaporated under reduced pressure to afford the product as a red-orange oil in quantitative yield. MS: MH+=439.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728010B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-33af28af016b497fa6bf2bf439a5eae2 |
| 출처 메모 | uspto-grants-2010_06 |