Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 2-Chloro-5-methoxy-1,3-benzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | HCID 178488270 | HCID 178488270 | — |
| 생성물 | 2-Chloro-5-methoxy-1,3-benzoxazole | HCID 11819712 | — |
반응 단계
The mixture containing 5-methoxybenzoxazole-2-thiol was heated in thionyl chloride with a drop of DMF. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried and concentrated. Purification on a silica gel column gave 2-chloro-5-methoxybenzoxazole as a white solid. MS: MH+=184.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728010B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-72ee57f529fb4716b4fa5ff71406d94e |
| 출처 메모 | uspto-grants-2010_06 |