2-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine → 4-(4-(3-Pyridyl)pyrimidin-2-yloxy)benzene-1,2-diamine

HRID 13476

반응식

HRID 13476 반응식
[N+:1]([C:4]1[CH:9]=[C:8]([O:10][C:11]2[N:16]=[C:15]([C:17]3[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=3)[CH:14]=[CH:13][N:12]=2)[CH:7]=[CH:6][C:5]=1[NH2:23])([O-])=O>CO.[Pd]>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:15]2[CH:14]=[CH:13][N:12]=[C:11]([O:10][C:8]3[CH:9]=[C:4]([NH2:1])[C:5]([NH2:23])=[CH:6][CH:7]=3)[N:16]=2)[CH:18]=1

참가 물질

4

반응물 1

HCID 220413402-Nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine

생성물 1

HCID 220413284-(4-(3-Pyridyl)pyrimidin-2-yloxy)benzene-1,2-diamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

The mixture containing 2-nitro-4-(4-(3-pyridyl)pyrimidin-2-yloxy)phenylamine in methanol with catalytic amount of 10% Pd/C was hydrogenated until disappearance of yellow color to yield 4-(4-(3-pyridyl)pyrimidin-2-yloxy)benzene-1,2-diamine. MS: MH+=279.

출처 및 근거

ORD 기록
ord-e2ea9dd830294ce3ba1f2a3948647513
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07728010B2

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