Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → L-Pro-Gly-L-Phe-L-Leu
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 1-(9H-Fluoren-9-ylmethyl) 2-(pentafluorophenyl) (2S)-1,2-pyrrolidinedicarboxylate | HCID 2733412 | — |
| 반응물 | H-Gly-phe-leu-OH | HCID 7016074 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | L-Pro-Gly-L-Phe-L-Leu | HCID 131726332 | — |
반응 단계
Fmoc-L-proline pentafluorophenyl ester (50 mg, 0.1 mmol) is dissolved in anhydrous DMF (1 mL) containing DIEA (17 μL, 0.1 mmol). About 0.5-1.0 mL of this solution is added to Gly-L-Phe-L-Leu ELAMS™ in a test tube and the tube vortexed for about 3 hours. The ELAMS™ are pelleted and washed with DMF (4×) and methylene chloride (2×). Deprotection can be effected by treatment with a solution of 20% piperidine in DMF for 30 min. The ELAMS™ are then washed with DMF (2×), ethanol (2×) and methylene chloride (2×) and dried at 60° C. for 4 hours. The identifier tag for each ELAMS™ is detected and recorded.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE039606E1 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-83ec640a78b440b69865030f3c36b147 |
| 출처 메모 | uspto-grants-2007_05 |