Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | N,N-dimethyl-1-(4-nitrophenyl)piperidin-4-amine | HCID 11086151 | — |
| 반응물 | Thiocarbonyl diimidazole | HCID 11412697 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | [1-(4-Isothiocyanato-phenyl)-piperidin-4-yl]-dimethyl-amine | HCID 21091577 | — |
반응 단계
Dimethyl-[1-(4-nitro-phenyl)-piperidin-4-yl]-amine (Example 2, 1.1 g, 5.0 mmol) was dissolved in DMF (5 mL). To the stirred solution, thiocarbonyl diimidazole (Aldrich, 1.18 g, 90%, 6 mmol) was added and the solution was stirred at room temperature for 80 minutes. The mixture was poured into water and extracted with diethyl ether. The extract was dried with sodium sulfate and concentrated to give a pale yellow solid. 1.12 g, 85%. MS (m+H)+: 262.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07211576B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-96af6633f0ff44f3afb9eaf504ffa333 |
| 출처 메모 | uspto-grants-2007_05 |