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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Water → (1S)-5-(1-Methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-2-yl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester

HRID 1348578
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인쇄 미리보기

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HRID 1348578 반응식
C(N(CC)CC)C.Cl.Cl[C:10]1[N:15]([CH3:16])[C:14](=[O:17])[CH:13]=[C:12]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[N:11]=1.[C:24]([O:28][C:29]([N:31]1[CH2:36][CH:35]2[CH2:37][C@H:32]1[CH2:33][NH:34]2)=[O:30])([CH3:27])([CH3:26])[CH3:25].O>CN(C)C=O>[C:24]([O:28][C:29]([N:31]1[CH2:36][CH:35]2[CH2:37][C@H:32]1[CH2:33][N:34]2[C:10]1[N:15]([CH3:16])[C:14](=[O:17])[CH:13]=[C:12]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[N:11]=1)=[O:30])([CH3:27])([CH3:25])[CH3:26]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

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HCID 962WaterHCID 8471TriethylamineHCID 230245272-chloro-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one hydrochlorideHCID 66592084(1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

생성물 1

HCID 68801880(1S)-5-(1-Methyl-6-oxo-4-pyridin-4-yl-1,6-dihydro-pyrimidin-2-yl)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester수율 72.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
20 °C

실험 절차

A mixture containing 10.7 ml (78.14 mmol) of triethylamine, 13.6 g (52.7 mmol) of 2-chloro-3-methyl-6-pyridin-4-yl-3H-pyrimidin-4-one hydrochloride (1:1), 6.0 g (30.24 mmol) of (1S)-2,5-diaza-bicyclo[2.2.1]heptane-2-carboxylic acid tert-butyl ester in 500 ml of anhydrous dimethylformamide is stirred at 20° C. for 6 h. Water is added to the cooled mixture and the resulting solution extracted with ethyl acetate. The combined extracts are washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride then-evaporated. The crude product is refluxed in diethylether for 1 h to afford 8.36 g of pure product as a brown solid.

후처리

  1. extractionthe resulting solution extracted with ethyl acetate
  2. washThe combined extracts are washed with saturated aqueous ammonium chloride and saturated aqueous sodium chloride
  3. customthen-evaporated
  4. temperatureThe crude product is refluxed in diethylether for 1 h

출처 및 근거

ORD 기록
ord-0c65aa05e37f49ecb6cd4748622a6d81
출처 데이터셋
uspto-grants-2007_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07211581B2

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