Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 2-Dibenzylamino-3-hydroxy-3-methyl-butyric acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | Lithium diisopropylamide | HCID 2724682 | — |
| 반응물 | Ethyl 2-(dibenzylamino)acetate | HCID 3553452 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Dibenzylamino-3-hydroxy-3-methyl-butyric acid ethyl ester | HCID 14824486 | 52.4% |
반응 단계
A solution of 11.3 g (40.0 mmol) dibenzylamino-acetic acid ethyl ester in 107 ml tetrahydrofuran and 107 ml toluene was stirred at −70° C. with 22 ml (44 mmol) lithium diisopropylamide (2M in heptane) for 30 minutes. 3.40 ml (46 mmol) acetone were added and stirring was continued overnight. The mixture was allowed to warm to room temprature, aqueous ammonium chloride solution was added. Extraction with diethylether and chromatography on silicagel with diethylether/heptane 1/2 yielded 7.16 g (52%) 2-dibenzylamino-3-hydroxy-3-methyl-butyric acid ethyl ester, MS m/e (%): 342.3 (M+H+, 100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07211573B2 |
| 출처 데이터셋 | uspto-grants-2007_05 |
| ORD ID | ord-c0e1b14399da4007b17d1580dce6c4c8 |
| 출처 메모 | uspto-grants-2007_05 |